(Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
custom-made
NR1H3
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
NR1H3
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Tian, Goldstein, Brown: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).
Aliases for NR1H3 蛋白
nuclear receptor subfamily 1 group H member 3 (NR1H3) 蛋白 nuclear receptor subfamily 1 group H member 3 (nr1h3) 蛋白 nuclear receptor subfamily 1, group H, member 3 (Nr1h3) 蛋白 nuclear receptor subfamily 1, group H, member 3 (nr1h3) 蛋白 AU018371 蛋白 im:7141239 蛋白 LXR 蛋白 LXR-a 蛋白 LXR-alpha 蛋白 LXRA 蛋白 LXRalpha 蛋白 NR1H3 蛋白 RLD-1 蛋白 RLD1 蛋白 Unr1 蛋白 wu:fd59b01 蛋白 zgc:113339 蛋白 zgc:158542 蛋白