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Notch (显示 NOTCH1 抗体) is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 (显示 ADAM10 抗体) processing
Our results provide molecular insight into the mechanisms by which NLRP4 (显示 NLRP4 抗体)-DTX4 targets TBK1 (显示 TBK1 抗体) for degradation.
The results indicate that DTX4 stable knockdown inhibits adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha (显示 CEBPA 抗体) and PPARgamma (显示 PPARG 抗体), arresting mitotic clonal expansion and regulating Wnt (显示 WNT2 抗体) signaling pathway.
Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
deltex 4 homolog
, E3 ubiquitin-protein ligase DTX4
, RING finger protein 155
, protein deltex-4
, deltex 4, E3 ubiquitin ligase
, deltex homolog 4
, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase DTX4