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Human ADAM10 ELISA Kit for Sandwich ELISA - ABIN414771
Van Crombruggen, Holtappels, De Ruyck, Derycke, Tomassen, Bachert: RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP. in The Journal of allergy and clinical immunology 2012
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Pharmacological inhibition of ADAM10 reduces sEphrin-B2 levels in bronchoalveolar lavage and prevents lung fibrosis in mice. Consistent with the mouse data, ADAM10-sEphrin-B2 signaling is upregulated in fibroblasts from human subjects with idiopathic pulmonary fibrosis.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR (显示 EGFR ELISA试剂盒)-ligands by differentially activating ADAM17 (显示 ADAM17 ELISA试剂盒) or ADAM10.
study confirms the importance of ICOSL (显示 ICOSLG ELISA试剂盒) shedding in ICOS (显示 ICOS ELISA试剂盒)/ICOSL (显示 ICOSLG ELISA试剂盒) function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL (显示 ICOSLG ELISA试剂盒) levels
Tspan3 (显示 TSPAN3 ELISA试剂盒) is a central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein (显示 APP ELISA试剂盒).
these results show that ADAM10-Notch (显示 NOTCH1 ELISA试剂盒) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.
Findings provide evidence that ADAM10, and not ADAM17 (显示 ADAM17 ELISA试剂盒), is indispensable for proper retinal development as a regulator of NOTCH (显示 NOTCH1 ELISA试剂盒) signaling.
this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch (显示 NOTCH1 ELISA试剂盒) ligands via Taok3 (显示 TAOK3 ELISA试剂盒)-mediated surface expression of ADAM10
Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.
ADAM10 was dispensable for alpha-toxin (显示 PLC ELISA试剂盒)-dependent xenophagic targeting of S. aureus, whereas a role for alpha-toxin (显示 PLC ELISA试剂盒) attack on the plasma membrane was confirmed.
ADAM10 was essentially involved in maxillofacial bone development. ADAM10 conditional knock-out KO mice present craniofacial dysmorphia and bone defects. Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.
Study reports the structure of the ADAM10 ectodomain, providing fundamental insights into how substrate selectivity and regulation of catalytic activity is achieved in this important representative of the ADAM family of metalloproteases.
Data suggest that ADAM10 associates directly with all members of a subgroup of tetraspanins having eight cysteines in the large extracellular domain ('TspanC8'): Tspan5 (显示 TSPAN5 ELISA试剂盒), Tspan10, Tspan14, Tspan15 (显示 TSPAN15 ELISA试剂盒), Tspan17, and Tspan33 (显示 TSPAN33 ELISA试剂盒). [REVIEW]
Results found ADAM10 expression under the regulation of MIR (显示 MLXIP ELISA试剂盒)-655 which binds the 3'-UTR (显示 UTS2R ELISA试剂盒) of ADAM10 mediating the progression of hepatocellular carcinoma.
Data suggest that activation of the metalloproteinase ADAM10 by signal peptide peptidase-like 3 (SPPL3) triggered by mutant BRAF(V600E) was a critical transformation event.
The ADAM17 (显示 ADAM17 ELISA试剂盒) messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 mRNA and protein levels did not differ significantly between NPs (显示 NPS ELISA试剂盒) and inferior turbinates (p > 0.05). ADAM10 and ADAM17 (显示 ADAM17 ELISA试剂盒) were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
study confirms the importance of ICOSL (显示 ICOSLG ELISA试剂盒) shedding in ICOS (显示 CTLA4 ELISA试剂盒)/ICOSL (显示 ICOSLG ELISA试剂盒) function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL (显示 ICOSLG ELISA试剂盒) levels
Inhibition of ADAM10 suppressed the expansion of NK cells and reduced the expression of CD16 (显示 CD16 ELISA试剂盒).
Platelet ADAM10 protein expression in patients with AD [Alzheimer's Disease] was positively influenced by serotoninergic medication
Endothelial Tspan5 (显示 TSPAN5 ELISA试剂盒)- and Tspan17-ADAM10 complexes may regulate inflammation by maintaining normal VE-cadherin (显示 CDH5 ELISA试剂盒) expression and promoting T lymphocyte transmigration.
A dramatic decline in ephrinB2 (显示 EFNB2 ELISA试剂盒) protein levels on the absence of flotillin-1 (显示 FLOT1 ELISA试剂盒) expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease ADAM10.
significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs
Data show that ADAM10 and APLP2 (显示 APLP2 ELISA试剂盒) are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.
Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.
N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
a disintegrin and metalloprotease domain 10a
, ADAM metallopeptidase domain 10
, disintegrin and metalloproteinase domain-containing protein 10
, ADAM10 metallopeptidase
, disintegrin and metalloproteinase domain-containing protein 10-like
, ADAM 10
, a disintegrin and metalloprotease domain (ADAM) 10
, a disintegrin and metalloprotease domain 10
, kuzbanian protein homolog
, mammalian disintegrin-metalloprotease
, a disintegrin and metalloproteinase domain 10
, a disintegrin and metallopeptidase domain 10
, myelin-associated metalloproteinase