This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Cao, Yang, Jin, Zhang, He, Zhan, Herman, Zhong, Guo: "Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 11, Issue 11, pp. 1912-1926, (2016) (PubMed).
Zhang, Cagatay, Amanai, Zhang, Kline, Castrillon, Ashfaq, Oz, Wharton: "Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4454-64, (2007) (PubMed).