This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010].
Tarlinton, Light, Metcalf, Harvey, Robb: "Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 8, pp. 4002-10, (2003) (PubMed).