(4-Nitrophenylphosphatase Domain and Non-Neuronal SNAP25-Like Protein Homolog 1 (NIPSNAP1))
This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Schoeber, Topala, Lee, Lambers, Ricard, van der Kemp, Huynen, Hoenderop, Bindels: "Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity." in: Pflügers Archiv : European journal of physiology, Vol. 457, Issue 1, pp. 91-101, (2008) (PubMed).
Surendran, Tyring, Matalon: "Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: possible role on cognitive defect seen in PKU." in: Neurochemistry international, Vol. 46, Issue 8, pp. 595-9, (2005) (PubMed).