NIPBL 产品
(Nipped-B like Protein (NIPBL))
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This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Recommended NIPBL 抗体
Product
Reactivity
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Cat. No.
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Datasheet
Reactivity
Rat
Application
IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (1)
Cat. No.
ABIN1714202
Quantity
100 μL
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Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN570861
Quantity
100 μg
Datasheet
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Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN7161618
Quantity
100 μg
Datasheet
Datasheet
Recommended NIPBL ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6205160
Quantity
96 tests
Datasheet
Datasheet
Recommended NIPBL 蛋白
Latest Publications for our NIPBL Products
: "NIPBL: a new player in myeloid cell differentiation." in: Haematologica, Vol. 104, Issue 7, pp. 1332-1341, (2019) (PubMed).: "Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer." in: Journal of translational medicine, Vol. 13, pp. 153, (2015) (PubMed).
: "Transcriptional dysregulation in NIPBL and cohesin mutant human cells." in: PLoS biology, Vol. 7, Issue 5, pp. e1000119, (2009) (PubMed).
: "Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance." in: PLoS biology, Vol. 4, Issue 8, pp. e242, (2006) (PubMed).
Synonyms and alternative names related to NIPBL
NIPBL, cohesin loading factor (NIPBL), Nipped-B homolog-like (NIPBLL), NIPBL, cohesin loading factor S homeolog (nipbl.S), Nipped-B homolog-like (LOC427439), nipped-B homolog b (Drosophila) (nipblb), nipped-B-like protein A (LOC100164947), NIPBL, cohesin loading factor (nipbl), Nipped-B homolog (Drosophila) (Nipbl), NIPBL, cohesin loading factor (Nipbl), 4921518A06Rik, 4933421G18Rik, C79399, CDLS, CDLS1, IDN3, Idn3, IDN3-B, nipbl, NIPBL, nipbla, Scc2, scc2, scc2-2, SCC2W, wu:fi33d08Protein level used designations for NIPBL
- SCC2 homolog
- delangin
- nipped-B-like protein
- sister chromatid cohesion 2 homolog
- Nipped-B homolog
- Scc2-2A
- Scc2-2B
- sister chromatid cohesion establishment factor 2
- Nipped-B homolog (Drosophila)
- nipped-B like a
- nipped-B-like protein B
- nipped-B-like protein-like
- delangin homolog
- LOW QUALITY PROTEIN: nipped-B-like protein
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