NGEF 蛋白
(Neuronal Guanine Nucleotide Exchange Factor (NGEF))
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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7 results
custom-made
NGEF
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
NGEF
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
NGEF
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
Aliases for NGEF 蛋白
neuronal guanine nucleotide exchange factor (NGEF) 蛋白neuronal guanine nucleotide exchange factor (Ngef) 蛋白
ARHGEF27 蛋白
Besh3 蛋白
EPHEXIN 蛋白
ephexin 蛋白
Ephexin-1 蛋白
ephexin-1 蛋白
Tims2 蛋白
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