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Human TRAF6 ELISA Kit for Sandwich ELISA - ABIN578203
Bilir, Engin, Can, Temi, Demirtas: The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia. in Medical oncology (Northwood, London, England) 2015
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we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (显示 MAPK8 ELISA试剂盒) activity by dissociating Atg9 (显示 ATG9A ELISA试剂盒)/mAtg9 (显示 ATG9A ELISA试剂盒) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
TRAF6 coiled-coil oligomerization domain primes its interaction with Ubc13 (显示 UBE2N ELISA试剂盒)/Ub~Ubc13 (显示 UBE2N ELISA试剂盒) to confer processivity. Long polyUb chain assembly requires coiled-coil domain of TRAF6
TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral ischemia/reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
Data provide a novel association between WDFY3 (显示 WDFY3 ELISA试剂盒) and the RANKL (显示 TNFSF11 ELISA试剂盒)-induced osteoclastogenesis pathway via the modulation of TRAF6.
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒)-regulated apoptosis and the p53 (显示 TP53 ELISA试剂盒)/PCNA (显示 PCNA ELISA试剂盒)- and ATM (显示 ATM ELISA试剂盒)/ATR (显示 ATR ELISA试剂盒)-Chk1 (显示 CHEK1 ELISA试剂盒)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (显示 TP53 ELISA试剂盒) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (显示 TP53 ELISA试剂盒) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (显示 STAT3 ELISA试剂盒), which is an essential step for STAT3 (显示 STAT3 ELISA试剂盒) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (显示 CUL5 ELISA试剂盒) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (显示 TNFSF11 ELISA试剂盒) enhances TNF (显示 TNF ELISA试剂盒)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (显示 TRAF3 ELISA试剂盒), a known inhibitor of osteoclastogenesis. (RANKL (显示 TNFSF11 ELISA试剂盒) = osteoclast differentiation factor (显示 TNFSF11 ELISA试剂盒); TNF (显示 TNF ELISA试剂盒) = tumor necrosis factor (显示 TNF ELISA试剂盒); Traf (显示 TRAF1 ELISA试剂盒) = TNF (显示 TNF ELISA试剂盒) receptor-associated factor)
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Results identified TRAF6 as a direct target of miR (显示 MLXIP ELISA试剂盒)-429, and its downregulation partially attenuates the effect of miR (显示 MLXIP ELISA试剂盒)-429 in promoting hepatocellular carcinoma cell proliferation and motility.
Compared with normal chondrocytes, the expression of miR (显示 MLXIP ELISA试剂盒)-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-kappaB (显示 NFKB1 ELISA试剂盒) increased in osteoarthritis chondrocytes.
We report two siblings with SCID (显示 PRKDC ELISA试剂盒) and an atypical phenotype of osteopetrosis (OP (显示 CSF1 ELISA试剂盒)). A biallelic microdeletion encompassing the 5' region of TRAF6, RAG1 (显示 RAG1 ELISA试剂盒) and RAG2 (显示 RAG2 ELISA试剂盒) genes was identified. TRAF6, a tumor necrosis factor (显示 TNF ELISA试剂盒) receptor-associated family member, plays an important role in T cell signaling and in RANKL (显示 TNFSF11 ELISA试剂盒)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported
miR (显示 MLXIP ELISA试剂盒)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4 (显示 TLR4 ELISA试剂盒), TRAF6, and p-IkappaBalpha (显示 NFKBIA ELISA试剂盒), subsequently leading to decreased NF-kappaB (显示 NFKB1 ELISA试剂盒) p65 (显示 GORASP1 ELISA试剂盒) nuclear translocation.
Taken together, these results define a novel role for miR (显示 MLXIP ELISA试剂盒)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (显示 YOD1 ELISA试剂盒) antagonizes TRAF6/p62 (显示 GTF2H1 ELISA试剂盒)-dependent IL-1 (显示 IL1A ELISA试剂盒) signaling to NF-kappaB (显示 NFKB1 ELISA试剂盒).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (显示 CRBN ELISA试剂盒) negatively regulates TLR4 (显示 TLR4 ELISA试剂盒) signaling via attenuation of TRAF6 and TAB2 (显示 TAB2 ELISA试剂盒) ubiquitination.
the polymorphisms in TLR-MyD88 (显示 MYD88 ELISA试剂盒)-NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6