蛋白简介

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. Stimulates promoter activity in the presence of p49- and p50-NF-kappa-B. Neither associates with DNA nor with p65-NF-kappa-B (By similarity).

Alternative names and synonyms associated with V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB)

• avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb) 抗体
• RELB proto-oncogene, NF-kB subunit (RELB) 抗体
• RELB proto-oncogene, NF-kB subunit (Relb) 抗体
• v-rel avian reticuloendotheliosis viral oncogene homolog B S homeolog (relb.S) 抗体

• GC-rich 抗体
• I-REL 抗体
• IREL 抗体
• REL-B 抗体
• relb-A 抗体
• 显示所有的同义词和别名
• shep 抗体
• XRelB 抗体

Protein level used designations for RELB

transcription factor RelB , v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) , v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 , avian reticuloendotheliosis viral (v-rel) oncogene related B , v-rel reticuloendotheliosis viral oncogene homolog B , transcription factor RelB homolog