anti-IL1RN (IL1RN) 抗体产品概述

Human Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. IL1RN -1129T>C (rs4251961) genotypes might be associated with a significant increase of acute pancreatitis risk in a Korean ethnic group.

2. In IL1RA gene, A1A1 genotype was associated with lower risk and A2A2 genotype with increased the risk of adverse outcome in severe community-acquired pneumonia in children in India

3. The IL1RN polymorphisms rs3181052, rs452204, and rs315919 were associated with a decreased risk of esophageal cancer in a Northwest Han Chinese population.

4. IL-1beta rs16944 and IL-1Ra VNTR variants are probably to be associated with susceptibility DPN risk in a Turkish cohort.

5. IL-1ss+3954 SNP mutations are significantly more common in patients with coronary slow flow phenomenon. It may suggest that the tendency for inflammation may contribute to the presence of this phenomenon.

6. this study describes association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population

7. results suggest that the cytokine IL-1Ra may play a role in Schizophrenia pathophysiology.

8. IL-1RN VNTR polymorphism is not associated with risk of psoriasis.

9. Interferon alpha2 and interferon gamma induce the degranulation independent production of VEGF-A and IL-1 receptor antagonist and other mediators from human mast cells.

10. VNTR not associated with male infertility

11. PDE4B-deficient mice displayed an increased circulating IL-1Ra, suggesting a protective role of PDE4B inactivation in vivo.

12. Study findings suggest that both promoter and exon polymorphisms of IL-1B gene have a significant role in the risk of developing Graves' disease (GD), whereas IL-1RN-VNTR variant has no association with GD in North India Kashmiri population.

13. Interleukin 1 receptor antagonist*A2 might be a risk factor for progressive vitiligo.

14. IL1-Ra is an independent predictor for adverse outcomes in patients with documented coronary artery disease.

15. Carrying allele IL1RN*2 had a strong association with idiopathic recurrent spontaneous abortion (iRSA) in Mexican women; this polymorphism codifies for a low-function protein, which may allow for increased activity of IL-1 pro-inflammatory axis in iRSA.

16. The single nucleotide polymorphism (SNP) of IL-1beta gene (rs3917356G>A) increased the risk of HCC in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA showed no significant association between Hepatocellular carcinoma patients and controls.

17. there was no sufficient evidence to support the association between IL-1RN 86-bp VNTR polymorphism and ischemic stroke (Meta-Analysis)

18. This study suggested that -511 C/T (rs16944) and -31 C/T (rs1143627) polymorphisms in IL-1beta gene may not be involved in RPL in Iranian Azeri women. Also the promoter polymorphism of the IL-1RN gene may not play a role in the susceptibility to RPL.

19. Serum interleukin 1 receptor antagonist (IL1RA) and granzyme B (GZMB) levels were markedly increased in Crohn's disease (CD) patients, suggesting that these markers can serve as biomarkers to identify gut inflammation.

20. this study reflects the importance of the IL1RN*2/2 genotype and its possible association in the pathogenesis of RA by regulation in the IL-1Ra production.

Pig (Porcine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. This study identified IL-1Ra as an early immunomodulatory mediator that could be involved in the immunopathogenesis of porcine reproductive and respiratory syndrome virus infections.

Rhesus Monkey Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.

2. common variation across the IL-1RN gene is strongly associated with IL-1RA levels.

Horse (Equine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. Using AAV2.5 capsid and equine IL-1Ra as a homologous transgene, a functional ceiling dose of approximately 5 x 10(12) viral genomes was previously identified, which elevated the steady state levels of eqIL-1Ra in synovial fluids by >40-fold over endogenous production for at least 6 months.

2. Using interleukin-1 receptor antagonist (IL-1Ra) as a secreted therapeutic reporter, scAAV vector plasmids containing codon-optimized cDNA for equine IL-1Ra (eqIL-1Ra) were generated, which produced eqIL-1Ra at levels 30- to 50-fold higher than the native sequence

3. This is the first study in an equine model to establish a dosing/redosing protocol, as well as examine the Nab response to capsid and supports further clinical investigation to determine the clinical efficacy of scAAVIL-1ra to treat osteoarthritis.

4. Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy.

Mouse (Murine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. these data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis

2. Beta cell IL-1Ra knockout mice had impaired insulin secretion, reduced beta cell proliferation, and decreased expression of islet proliferation genes, along with impaired glucose tolerance.

3. Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice.

4. Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis.

5. The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia.

6. the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas

7. we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells.

8. results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo.

9. Allo-transplantation of mesenchymal stem cells reduces Con A liver injury by increasing IL10 production through an IL1Ra dependent macrophage switch.

10. results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.

11. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production.

12. IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE(-/-) mice.

13. IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade.

14. These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.

15. These findings demonstrate a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner.

16. Leading to enhanced interleukin-1 receptor antagonist (IL-1RA) production.

17. Results suggest that the IL-1R1/IL-1ra complex regulates specific ethanol behaviors and affects the sensitivity to flurazepam sedation

18. IL-1Ra may have a protective effect upon EBOV infection.

19. IL-1ra regulates baseline GABAergic transmission in the central amygdala and is critical for the ethanol effects at these synapses.

20. normalization of IL-1Ra in obesity improved insulin sensitivity due to decreased inflammation in the liver and improved hepatic insulin sensitivity and these effects were independent of changes in body weight.

Rabbit Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

1. IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis