This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008].
François, DOrlando, Fatone, Touvier, Pessina, Meneveri, Brunelli: "Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1." in: PLoS ONE, Vol. 7, Issue 8, pp. e43335, (2012) (PubMed).
Kurita, Kuwajima, Nishimura, Yoshikawa: "Necdin downregulates CDC2 expression to attenuate neuronal apoptosis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 46, pp. 12003-13, (2006) (PubMed).
Kuwajima, Taniura, Nishimura, Yoshikawa: "Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40484-93, (2004) (PubMed).
Niinobe, Koyama, Yoshikawa: "Cellular and subcellular localization of necdin in fetal and adult mouse brain." in: Developmental neuroscience, Vol. 22, Issue 4, pp. 310-9, (2000) (PubMed).
Aliases for NDN 抗体
necdin, MAGE family member (NDN) 抗体 necdin (Ndn) 抗体 necdin, MAGE family member (Ndn) 抗体 AI528698 抗体 HsT16328 抗体 LOC574323 抗体 NDN 抗体 Peg6 抗体 PWCR 抗体