Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
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Jones, Jakubowicz, Pitossi, Maurer, Hemmings: "Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4171-5, (1991) (PubMed).
Aliases for NDFIP2 抗体
Nedd4 family interacting protein 2 S homeolog (ndfip2.S) 抗体 Nedd4 family interacting protein 2 (NDFIP2) 抗体 Nedd4 family interacting protein 2 (ndfip2) 抗体 Nedd4 family interacting protein 2 (Ndfip2) 抗体 0710001O20Rik 抗体 2810436B12Rik 抗体 9130207N19Rik 抗体 DKFZp459H0627 抗体 MGC68708 抗体 mKIAA1165 抗体 N4WBP5A 抗体 N4wbp5a 抗体