Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).
Youle, Lista, Bouton, Kunzelmann, Wilson, Cottee, Purkiss, Morris, Neil, Taylor, Swanson: "Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN." in: The Journal of biological chemistry, Vol. 301, Issue 4, pp. 108336, (2025) (PubMed).
Aliases for N4BP1 抗体
NEDD4 binding protein 1 (N4BP1) 抗体 NEDD4 binding protein 1 (N4bp1) 抗体 Nedd4 binding protein 1 (N4bp1) 抗体 nedd4 binding protein 1 (n4bp1) 抗体 nedd4 binding protein 1 L homeolog (n4bp1.L) 抗体 AI481586 抗体 C81621 抗体 RGD1305179 抗体 wu:fi03b05 抗体 zgc:66437 抗体