This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008].
Ding, Dellisanti, Ko, Czajkowski, Puglielli: "The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 32044-55, (2014) (PubMed).
Ding, Ko, Pehar, Kotch, Peters, Luo, Salamat, Puglielli: "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8424-33, (2012) (PubMed).