This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
custom-made
NAT1
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
NAT1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
van Eijl, Zhu, Cupitt, Gierula, Götz, Fritsche, Edwards: "Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling." in: PLoS ONE, Vol. 7, Issue 7, pp. e41721, (2012) (PubMed).
Millner, Doll, Cai, States, Hein: "Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 1, pp. 198-204, (2011) (PubMed).