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抗Mouse (Murine) RAMP3 抗体:
抗Human RAMP3 抗体:
抗Rat (Rattus) RAMP3 抗体:
Human Polyclonal RAMP3 Primary Antibody for IF (p), IHC (p) - ABIN1386642
Qiao, Wang, Wang, Zhao, Zhang, Han, Peng: Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction. in Nephrology (Carlton, Vic.) 2015
the cardiovascular response of Ramp1 (显示 RAMP1 抗体)(-/-), Ramp2 (显示 RAMP2 抗体)(+/-), Ramp3(-/-), Ramp1 (显示 RAMP1 抗体)(-/-)/Ramp3(-/-) double-knockout (dKO), and Calcrl (显示 CALCRL 抗体)(+/-) mice to AM and CGRP (显示 CALCA 抗体) were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR (显示 CALCR 抗体)/RAMP1 (显示 RAMP1 抗体) heterodimer, but that AM signaling via CLR (显示 CALCR 抗体)/RAMP2 (显示 RAMP2 抗体) and CLR (显示 CALCR 抗体)/RAMP3 also contributes to some hypotensive action.
RAMP3 regulates drainage through lymphatic vessels.
G-protein-coupled receptor 30 (显示 GPER 抗体) interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD (显示 ADM2 抗体)), calcitonin receptor-like receptor (CRLR (显示 CALCRL 抗体)), and RAMP1 (显示 RAMP1 抗体) and RAMP2 (显示 RAMP2 抗体).
these data demonstrate a sex-dependant, cardioprotective role of RAMP3 in the setting of chronic hypertension.
role in cell surface expression of CRLR (显示 CALCRL 抗体)/RAMP heterodimeric receptors
RAMP2 (显示 RAMP2 抗体) and RAMP3 have distinct physiological functions throughout embryogenesis, adulthood, and old age
tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation (显示 HELLS 抗体) profile throughout the Ramp3-WAP-Tbrg4 (显示 TBRG4 抗体) locus.
interaction of RAMP2 (显示 RAMP2 抗体) or RAMP3 with CLR (显示 DCLK3 抗体) induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.
the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR (显示 DCLK3 抗体) and RAMP2 (显示 RAMP2 抗体), but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor (显示 CALCRL 抗体)) N-terminal domain; RAMP3/RAMP2 (显示 RAMP2 抗体)/RAMP1 (显示 RAMP1 抗体) appear to alter accessibility of specific residues at CALCRL (显示 CALCRL 抗体)-RAMP interface.
The expression of RAMP3 is downregulated in the fetal lung with increasing gestational age.
the RAMP3 TMD (显示 TTN 抗体) participates in the negative regulation of CLR (显示 DCLK3 抗体)/RAMP3 internalization.
Data show that LOXL2 (显示 LOXL2 抗体) and RAMP3 are strongly coexpressed in human colon, breast, and gastric carcinomas but not in normal colon or gastric epithelial cells.
This study provides insight into the role of three amino acid changes in human RAMP3.
Morphological fluorescence techniques, bioluminescence resonance energy transfer, and bimolecular fluorescence complementation analysis demonstrate that the secretin receptor (显示 SCTR 抗体) associates specifically with RAMP3, but not with RAMP1 (显示 RAMP1 抗体) or RAMP2 (显示 RAMP2 抗体).
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR (显示 CALCRL 抗体)) in HEK (显示 EPHA3 抗体)-293 cells
results show the presence of calcitonin receptor-like receptor (显示 CALCRL 抗体) and receptor activity-modifying proteins in middle meningeal, middle cerebral, pial, and superficial temporal vessels
Data indicate that adrenomedullin (显示 ADM 抗体) mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (显示 CALCRL 抗体), RAMP2 (显示 RAMP2 抗体) and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells.
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
receptor (calcitonin) activity modifying protein 3
, receptor activity modifying protein 3
, receptor activity-modifying protein 3
, receptor (G protein-coupled) activity modifying protein 3
, Receptor activity-modifying protein 3
, CRLR activity-modifying protein 3
, calcitonin receptor-like receptor activity modifying protein 3
, calcitonin-receptor-like receptor activity-modifying protein 3
, receptor-activity-modifying protein 3