This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008].
Hurlin, Quéva, Koskinen, Steingrímsson, Ayer, Copeland, Jenkins, Eisenman: "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation." in: The EMBO journal, Vol. 14, Issue 22, pp. 5646-59, (1996) (PubMed).
Aliases for MXD4 抗体
MAX dimerization protein 4 (MXD4) 抗体 Max dimerization protein 4 (Mxd4) 抗体 MAX dimerization protein 4 S homeolog (mxd4.S) 抗体 microRNA 4800 (MIR4800) 抗体 MAX dimerization protein 4 (mxd4) 抗体 MAX dimerization protein 4 (Mxd4) 抗体 2810410A03Rik 抗体 bHLHc12 抗体 bhlhc12 抗体 MAD4 抗体 Mad4 抗体 MGC84841 抗体 MST149 抗体 mst149 抗体 MSTP149 抗体 mstp149 抗体 MXD4 抗体 xmad4 抗体