This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Popular MXD1 抗体
Latest Publications for our MXD1 抗体
Ullius, Lüscher-Firzlaff, Costa, Walsemann, Forst, Gusmao, Kapelle, Kleine, Kremmer, Vervoorts, Lüscher: "The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification." in: Nucleic acids research, Vol. 42, Issue 11, pp. 6901-20, (2014) (PubMed).
Aliases for MXD1 抗体
MAX dimerization protein 1 (MXD1) 抗体 MAX dimerization protein 1 (mxd1) 抗体 MAX dimerization protein 1 L homeolog (mxd1.L) 抗体 MAX dimerization protein 1 (Mxd1) 抗体 max dimerization protein 1 (Mxd1) 抗体 AW122478 抗体 BHLHC58 抗体 MAD 抗体 Mad 抗体 Mad-1 抗体 MAD1 抗体 Mad1 抗体 MXD1 抗体 si:dkey-202n14.4 抗体 xmad1 抗体