Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008].
Mizrachi Nebenzahl, Blau, Kushnir, Shagan, Portnoi, Cohen, Azriel, Malka, Adawi, Kafka, Dotan, Guterman, Troib, Fishilevich, Gershoni, Braiman, Mitchell, Mitchell, Porat, Goliand, Chalifa Caspi et al.: "Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as ..." in: PLoS ONE, Vol. 11, Issue 3, pp. e0150320, (2016) (PubMed).