This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Yoshikawa, Satoh, Tamura, Wei, Bilasy, Edamatsu, Aiba, Katagiri, Kinashi, Nakao, Kataoka: "The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes." in: Molecular biology of the cell, Vol. 18, Issue 8, pp. 2949-59, (2007) (PubMed).
Mitin, Ramocki, Zullo, Der, Konieczny, Taparowsky: "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22353-61, (2004) (PubMed).
Kimmelman, Nuñez Rodriguez, Chan: "R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade." in: Molecular and cellular biology, Vol. 22, Issue 16, pp. 5946-61, (2002) (PubMed).
Aliases for MRAS 抗体
RAB5D, member RAS oncogene family S homeolog (rab5d.S) 抗体 muscle RAS oncogene homolog (MRAS) 抗体 RAB5D, member RAS oncogene family (rab5d) 抗体 muscle and microspikes RAS (Mras) 抗体 muscle RAS oncogene homolog (Mras) 抗体 2900078C09Rik 抗体 AI326250 抗体 m-ras 抗体 M-RAs 抗体 r-ras3 抗体 R-RAS3 抗体 rras3 抗体 RRAS3 抗体