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PEX2 is required for peroxisome autophagy during starvation.
the carrier frequencies for two PEX2 mutations causative of the severe Zellweger syndrome (显示 PEX1 蛋白) spectrum phenotype in Ashkenazi Jews
Ischemic wound healing is retarded in mice subjected to recombinant PEX2 injections or viral transduction with PEX2-lentivurus.
Genetic screening of PEX2 and other PEX (显示 PHEX 蛋白) genes involved in peroxisomal biogenesis is warranted in children and adults with ARCA
The cause of the syndrome in this patient was a point mutation that resulted in the premature termination of peroxisome assembly factor-1.
Data indicate that the induction of SREBP-2 (显示 SREBF2 蛋白) and ER stress pathways is independent of PPARalpha (显示 PPARA 蛋白) activation in livers of newborn peroxisome assembly factor 1 (Pex2) knockout mice.
This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein.
35 kDa peroxisomal membrane protein
, RING finger protein 72
, peroxisomal membrane protein 3, 35kDa
, peroxisome assembly factor 1
, peroxisome assembly factor-1
, peroxisome biogenesis factor 2
, Zellweger syndrome homolog
, peroxisomal membrane protein 3, 35 kDa
, peroxisomal membrane protein 3 (Zellweger syndrome)
, peroxisomal biogenesis factor 2
, peroxin 2
, peroxisomal membrane protein 3, 35kDa (Zellweger syndrome)