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抗Human Abcd2 抗体:
抗Mouse (Murine) Abcd2 抗体:
抗Rat (Rattus) Abcd2 抗体:
ABCD1 (显示 ABCD1 抗体) and ABCD2 are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 (显示 ABCD3 抗体) is involved in the transport of branched chain acyl-CoA (显示 GNPAT 抗体) into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 (显示 NDUFB3 抗体) from lysosomes into the cytosol.
13-cis (显示 CISH 抗体)-retinoic acid induces ABCD2 expression in human monocytes/macrophages.
ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack
results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA
The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin (显示 CTNNB1 抗体) and TCF-4 (显示 TCF4 抗体).
LXRalpha (显示 NR1H3 抗体) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (显示 NR1H3 抗体) binding sites
Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.
These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy.
LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19 (显示 PEX19 抗体). This interaction is mediated by amino acids 1-218 of ALDRP.
ALDRP interacts with PMP70 (显示 ABCD3 抗体). This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 (显示 ABCD3 抗体) C-terminus [338-659]. This interaction was demonstrated using human PMP70 (显示 ABCD3 抗体) and mouse ALDRP.
ABCD1 (显示 ABCD1 抗体) and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1 (显示 ABCD1 抗体)-deficient mice
The absence of ABCD2 altered expression of gene clusters associated with lipid metabolism, including PPARalpha (显示 PPARA 抗体) signaling.
ABCD2 is a sterol regulatory element binding protein (显示 CNBP 抗体) target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.
Evidence against the adrenoleukodystrophy-related gene acting as a modifier of X-adrenoleukodystrophy.
Abcd1 (显示 ABCD1 抗体) and Abcd2 gene silencing sensitizes astrocytes for inflammation and may have a role in X-adrenoleukodystrophy
ABCD2 plays a role in th degradation of long-chain saturated and omega9-monounsaturated fatty acids and in the synthesis of docosahexanoic acid.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown\; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
ATP-binding cassette, sub-family D, member 2
, ATP-binding cassette, sub-family D (ALD), member 2
, ATP-binding cassette sub-family D member 2
, ATP-binding cassette sub-family D member 2-like
, adrenoleukodystrophy-like 1
, adrenoleukodystrophy-related protein
, adrenoleukodystrophy related