Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008].
Sena, Mariani, Marzona, Benincasa, Ponz de Leon, Palumbo, Roncucci: "Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages." in: International journal of oncology, Vol. 41, Issue 1, pp. 260-6, (2012) (PubMed).
Kaituu-Lino, Palmer, Tuohey, Ye, Tong: "MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin." in: PLoS ONE, Vol. 7, Issue 6, pp. e39864, (2012) (PubMed).
Jung, Römer, Keyszer, Lein, Kristiansen, Schnorr, Loening, Jung: "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue." in: The Prostate, Vol. 55, Issue 2, pp. 89-98, (2003) (PubMed).
Nakamura, Ueno, Yamashita, Shimada, Yamamoto, Noguchi, Fujimoto, Sato, Seiki, Okada: "Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas." in: Cancer research, Vol. 59, Issue 2, pp. 467-73, (1999) (PubMed).