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polarity-induced spatiotemporal control of Rok and Pkn (显示 PKN1 蛋白) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (显示 AMH 蛋白)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (显示 TNC 蛋白) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (显示 FHOD1 蛋白) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (显示 EGFR 蛋白) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (显示 CD44 蛋白) interaction with p115RhoGEF (显示 ARHGEF1 蛋白) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (显示 PI3 蛋白)-kinase membrane localization, AKT (显示 AKT1 蛋白) signaling, and cytokine (M-CSF (显示 CSF1R 蛋白)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (显示 ZYX 蛋白)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
by differentially affecting CyPA (显示 PPIA 蛋白) and Bsg expressions, ROCK1 protects and ROCK2 (显示 ROCK2 蛋白) jeopardizes the heart from pressure-overload heart failure with postcapillary pulmonary hypertension, for which celastrol may be a promising agent.
Data indicate that Rho-associated protein kinase (ROCK)-dependent intermittent T cell migration regulates tissue-sampling during acute lung injury.
findings are the first to show that astrocytes exposed to MeHg showed increased cleavage/activation of ROCK-1, which was independent of the small GTPase (显示 RACGAP1 蛋白) RhoA (显示 RHOA 蛋白)
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 (显示 CRMP1 蛋白) at Ser616, was shown by luciferase assay to be directly regulated by FOXO1 (显示 FOXO1 蛋白). These findings suggested that FOXO1 (显示 FOXO1 蛋白) is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 (显示 FOXO1 蛋白) may serve as a therapeutic target for microvascular complications of diabetes.
A specific inhibitor of ROCK, Y-27632, was used to examine the role of ROCK in mouse colitis models. ROCK1 and ROCK2 (显示 ROCK2 蛋白) were silenced respectively using RNA interference in Caco-2 cells. The expression of tight junction proteins and the downstream molecules of ROCK were assessed
GTP (显示 AK3 蛋白)-RhoA (显示 RHOA 蛋白) and ROCK1 expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
Irisin (显示 FNDC5 蛋白) replenishment in mCaROCK1 mice partially reversed insulin (显示 INS 蛋白) resistance.
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB (显示 NFKB1 蛋白) pathways.
we define how ROCK/LIMK (显示 LIMK1 蛋白) pathway regulates mast cell development and functions
These results indicate shear stress induced vascular smooth muscle cell contraction was mediated by cell surface glycocalyx via a ROCK-MLC phosphatase (MLCP) pathway, providing evidence of the glycocalyx mechanotransduction in myogenic response.
he phosphorylation of the MP inhibitory MYPT1(T850) and the regulatory PRMT5(T80) residues as well as the symmetric dimethylation of H2A/4 were elevated in human hepatocellular carcinoma and in other types of cancers.
silencing of URG11 altered the expression levels of cell cycleassociated genes, epithelialmesenchymal transitionassociated genes, and RhoA and ROCK1 protein levels. Thus, the results of the present study suggest that URG11 may be a potential therapeutic target, which may be important to inhibit the development and progression of prostatic hyperplasia.
Results suggested that the RhoA (显示 RHOA 蛋白)/ROCK1 pathway activated by excessive ROS (显示 ROS1 蛋白) is responsible for profilin-1 (显示 PFN1 蛋白)-mediated endothelial damage.
restoration of ROCK1 expression significantly reversed the suppressive effect of miR (显示 MLXIP 蛋白)-361-5p on cell proliferation, migration, and invasion in papillary thyroid cancer cells.
The pathways involved in the effect of ROCK1 in human corneal epithelial cells was preliminarily explained by detecting changes of TLR4 (显示 TLR4 蛋白)-mediated NF-kB and ERK (显示 EPHB2 蛋白) signaling.
ROCK1 plays a role in oxLDL-induced cell adhesion by regulating adhesion molecules expression.
Study showed that ROCK1 was overexpressed in retinoblastoma (RB) tissues and inversely correlated with miR448 expression. Furthermore, ROCK1 silencing induced effects on the proliferation, invasion and apoptosis of RB cells similar to those observed following miR448 overexpression. Importantly, miR448 targeted ROCK1 to inhibit the activation of the PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) signaling pathway in RB.
These results suggested a protective role of miR (显示 MLXIP 蛋白)-145 in high glucose-treated vascular smooth muscle cells by suppressing ROCK1.
the level of ROCK1 was markedly increased in osteosarcoma cancer tissues compared to that of noncancerous tissues.
Results indicate that ROCK1 and ROCK2 (显示 ROCK2 蛋白) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (显示 LIMK1 蛋白)/cofilin (显示 CFL1 蛋白) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (显示 MAPK14 蛋白) phosphorylation and MMP13 (显示 MMP13 蛋白) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (显示 RHOA 蛋白)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (显示 DDX4 蛋白) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1