The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011].
Dvash, Har-Tal, Barak, Meir, Rubinstein: "Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage." in: Nature communications, Vol. 6, pp. 10112, (2015) (PubMed).
Yang, Lou: "Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats." in: Biochemical pharmacology, Vol. 73, Issue 5, pp. 724-35, (2007) (PubMed).
Yang, Huang, Chen, Xu, Chen, Kong, Lou: "Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats." in: The Journal of surgical research, Vol. 140, Issue 1, pp. 36-44, (2007) (PubMed).