This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2. [provided by RefSeq, Jul 2008].
Leung, Yeung, Yip, Pradeep, Balasubramanian, Liu, Wong, Mangala, Armaiz-Pena, Lopez-Berestein, Sood, Birrer, Mok: "Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential." in: Nature communications, Vol. 5, pp. 5092, (2014) (PubMed).
Luistro, He, Smith, Packman, Vilenchik, Carvajal, Roberts, Cai, Berkofsky-Fessler, Hilton, Linn, Flohr, Jakob-Røtne, Jacobsen, Glenn, Heimbrook, Boylan: "Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties." in: Cancer research, Vol. 69, Issue 19, pp. 7672-80, (2009) (PubMed).
Aliases for MFAP5 抗体
microfibrillar associated protein 5 (MFAP5) 抗体 microfibril associated protein 5 (MFAP5) 抗体 microfibrillar associated protein 5 (Mfap5) 抗体 microfibril associated protein 5 (Mfap5) 抗体 MAGP-2 抗体 MAGP2 抗体 MFAP5 抗体 MP25 抗体