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The role of methylation in the regulation of CYP24A1 expression in human colorectal cancer showed that DNA methylation (显示 HELLS 蛋白) is involved in the regulation of CYP24A1 expression in a cell-dependent manner.
SREBP1 (显示 SREBF1 蛋白) trans-activates CYP24A1 expression through SREBP binding elements present in the promoter.
There was no significant difference in CYP24A1 expression between epileptic patients and normal subjects.
No significant differences were found between ischemic stroke patients and controls in terms of CYP24A1 rs927650 and CYP2R1 (显示 CYP2R1 蛋白) rs10741657 genotype frequencies. Polymorphic allele frequencies of CYP24A1 rs927650 and CYP2R1 (显示 CYP2R1 蛋白) rs10741657 were 0.414 and 0.660 in stroke patients, respectively.
There were no associations between CYP24A1 polymorphisms and overall cancer risks
colorectal cancer (CRC (显示 CALR 蛋白)) patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 and CYP27B1 (显示 CYP27B1 蛋白). Polymorphic genotypes cause a lower correlation between the forms of vitamin D.
Single nucleotide polymorphisms in CYP24A1 has a statistically significant association with risk of the colonic polyps, colon cancer, and ulcerative colitis in a Chinese population.
The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D.
Dietary habits, lifestyle, and polymorphisms in VDR (显示 CYP27B1 蛋白) (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (显示 CYP27B1 蛋白) (rs10877012) were associated with a higher risk of colorectal cancer
The local regulation of vitamin D in sinonasal tissue during chronic rhinosinusitis may be independent of serum 25(OH)D levels. Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 (显示 CYP27B1 蛋白) and increased transcription of the catabolic gene CYP24A1.
CYP24A1 activity is not essential for intramembranous bone formation.
results link CYP24 activity to the pathophysiology of FGF23 (显示 FGF23 蛋白)-dependent renal phosphate wasting states and implicate pharmacologic CYP24 inhibition as a therapeutic adjunct for their treatment.
Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase mRNA levels and for maintaining normal serum 1,25(OH)2D.
Data suggest that control of CYP24A1 increase during diabetes has a beneficial effect on senescence induction and caspase-3 (显示 CASP3 蛋白) increased expression.
the mechanism through which 1,25(OH)(2)D(3) induces the CYP24A1 enzyme
The expression of vitamin D 24-hydroxylase gene was directly regulated by serum calcium rather than 25-hydroxyvitamin D 1 alpha-hydroxylase.
Results show that Inhibition of 24-OHase activity modulates serum calcitriol PK in normal C3H/HeJ mice.
Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture hea
1,25(OH)2D is the preferred substrate for CYP24 in murine kidney mitochondria.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
1,25-@dihydroxyvitamin D3 24-hydroxylase
, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
, cytochrome P450 24A1
, cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
, cytochrome P450-CC24
, exo-mitochondrial protein
, vitamin D 24-hydroxylase
, vitamin D(3) 24-hydroxylase
, 25-hydroxyvitamin D-24-hydroxylase
, cytochrome P450, 24
, cytochrome P450, 24a1
, 25-hydroxyvitamin D3 24-hydroxylase
, Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)
, cytochrome P450, subfamily 24
, 25-hydroxyvitamin D3-24-hydroxylase