This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Vijayalingam, Chinnadurai: "Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex." in: Journal of virology, Vol. 87, Issue 6, pp. 3425-34, (2013) (PubMed).