(Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2))
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008].
Guo, Cao, Qin, Zhao, Wang, Li, Xin, Shu, Zhou: "Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro." in: Biochemical and biophysical research communications, Vol. 458, Issue 1, pp. 77-81, (2015) (PubMed).