MBD2 蛋白
(Methyl-CpG Binding Domain Protein 2 (MBD2))
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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6 results
MBD2
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
> 90 %
SDS, WB, Imm, PC
custom-made
MBD2
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
MBD2
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Aliases for MBD2 蛋白
methyl-CpG binding domain protein 2 (MBD2) 蛋白methyl-CpG binding domain protein 2 (Mbd2) 蛋白
methyl-CpG binding domain protein 2 (mbd2) 蛋白
methyl-CpG binding domain protein 2 S homeolog (mbd2.S) 蛋白
DMTase 蛋白
MBD2 蛋白
MBD2a 蛋白
NY-CO-41 蛋白
wu:fa97f06 蛋白
zgc:111862 蛋白
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