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These findings suggest that Cdc2 (显示 CDK1 蛋白) is positively associatd with the development of taxol resistance. The Cdc2 (显示 CDK1 蛋白) inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin.
these results showed that stathmin expression was significantly up-regulated in LAC (显示 LCT 蛋白), which may act as a biomarker for LAC (显示 LCT 蛋白). Furthermore, silence of stathmin inhibiting LAC (显示 LCT 蛋白) cell growth indicated that stathmin may be a promising molecular target for LAC (显示 LCT 蛋白) therapy.
Increased stathmin correlated with pathologic grade, lymphatic invasion, advanced stage and poor survival of non-small cell lung cancer (NSCLC), which indicated that stathmin could serve as a potential biomarker of NSCLC
Results showed that patients with cancer displayed a higher stathmin expression than those of non-cancer individuals, and overexpression of stathmin correlated with tumor cell differentiation, lymph node invasion and high TNM (显示 ODZ1 蛋白) stage. [review]
High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Pancreatic Cancer.
miR (显示 MLXIP 蛋白)-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in gallbladder cancer, highlighting its promising therapeutic value.
overexpression correlates with poorer prognosis and interacts with p53 (显示 TP53 蛋白) in oral squamous cell carcinoma
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
STMN1 gene and miRNA-223 expression profiles in non-tumor liver tissues were predictive of the risk for multicentric hepatocellular carcinoma recurrence.
The crucial role of FOXM1 (显示 FOXM1 蛋白) and STMN1 in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 and FOXM1 (显示 FOXM1 蛋白) in NSCLC cells.
EGFR (显示 EGFR 蛋白) suppression of mitotic regulators including Rcc2 (显示 RCC2 蛋白) and Stathmin 1 are a mechanism for catagen induction in mouse skin
We identified stathmin as a key molecule aiding in septin (显示 SEPT6 蛋白)-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7 (显示 SEPT7 蛋白)-null fibroblasts
Overexpressing stathmin reduces complement receptor 3 (显示 ITGAM 蛋白)-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages.
Stathmin cooperates with p27(kip1 (显示 CDKN1B 蛋白)) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.
The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation.
Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons
Stathmin mutations disrupt changes in microtubule stability, GluA2 (显示 GRIA2 蛋白) localization, synaptic plasticity and memory.
Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA (显示 SMN1 蛋白) pathology.
stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers.
results demonstrate the mechanism of stathmin-dependent control of MT dynamics, Rho signaling, and permeability
Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
leukemia-associated phosphoprotein p18
, oncoprotein 18
, phosphoprotein 19
, phosphoprotein p19
, stathmin 1/oncoprotein 18
, transmembrane protein C1orf215
, leukemia associated phosphoprotein p18
, leukemia-associated gene protein
, leukemia-associated cytosolic phosphoprotein stathmin
, stathmin 1 a
, stathmin 1/oncoprotein 18b
, stathmin 1
, stathmin 1 b
, stathmin 1b
, stathmin clone XO35