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SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region.
SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44
Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway.
SRGN expression is significantly upregulated in human masticatory mucosa during wound healing
Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases.
The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression
These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development.
These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells.
The reduced expression of SRGN was accompanied by elevated levels of E-cadherin.
These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM.
These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT.
Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I.
This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction.
Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1.
Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients.
Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity.
Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1.
proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin
cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression
serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells
serglycin produced in lipopolysaccharide-induced inflammation in normal mouse chondrocytes is able to modulate inflammation by interacting with CD44 receptor, suggesting a possible key role in the cartilage inflammation.
Findings indicate that PRG-1 deficiency led to over-excitability caused by an altered LPA/LPA2-R signaling inducing a behavioral phenotype typically observed in animal models for psychiatric disorders.
this study shows that the serglycin-deficient mice are more susceptible to Trichinella spiralis infection and display an unbalanced immune response
Data suggest that serglycin proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells.
serglycin deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks.
serglycin plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B, whereas granzyme A is unaffected
Wild-type mast cells efficiently degraded exogenous or endogenously produced IL-13 upon degranulation,whereas serglycin -/- mast cells completely lacked this ability.
Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin.
Cells lacking mouse mast cell protease 6 exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the pro-apoptotic function of serglycin is due to downstream effects of proteases that are complex-bound to serglycin
The PRG-1 transcription is initiated at multiple transcription start site and no influence on expression in vivo by Nex1 deficiency.
serglycin proteoglycan as a novel player in mast cell apoptosis.
serglycin proteoglycan is dispensable for normal secretion and activity of mast cell proteases in response to peritoneal infection with T. gondii.
SG proteoglycan has a key role in mast cell function
serglycin is the major proteoglycan secreted by peritoneal macrophages and the macrophage serglycin may have a role in regulating secretion of tumor necrosis factor-alpha
The reduced amounts of proteases in the absence of serglycin is not caused by missorting, but rather that serglycin may be involved in the retention of the proteases after their entry into secretory vesicles
Serglycin is of crucial importance for assembly of mature mucosal mast cell granules, but the specific dependence on SG for storage varies between individual granule constituents.
Neutrophil elastase depends on serglycin proteoglycan for localization in granules.
SG is crucial for platelet function and thrombus formation
Histamine and serotonin storage in mast cells is dependent on serglycin proteoglycan.
the present report points to a novel, previously unrecognized role for serglycin proteoglycan in regulating the kinetics of antiviral CD8(+) T cell responses
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
hematopoetic proteoglycan core peptide
, hematopoetic proteoglycan core protein
, hematopoietic proteoglycan core protein
, platelet proteoglycan core protein
, proteoglycan 1, secretory granule
, proteoglycan protein core for mast cell secretory granule
, secretory granule proteoglycan core peptide
, secretory granule proteoglycan core protein
, serglycin proteoglycan
, mastocytoma proteoglycan core protein
, proteoglycan, secretory granule
, PG19 core protein
, chondroitin sulfate proteoglycan core protein
, cytolytic granule proteoglycan core protein
, proteoglycan 10K core protein
, proteoglycan peptide core protein