Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].
Latest Publications for our Matrix Metallopeptidase 1 (Interstitial Collagenase) 蛋白
Tan, Fan, Ma, Qiu, Li, Yan: "Injectable gel scaffold based on biopolymer microspheres via an enzymatic reaction." in: Advanced healthcare materials, Vol. 3, Issue 11, pp. 1769-75, (2014) (PubMed).
Templeton, Brown, Levy, Margulies, Liotta, Stetler-Stevenson: "Cloning and characterization of human tumor cell interstitial collagenase." in: Cancer research, Vol. 50, Issue 17, pp. 5431-7, (1990) (PubMed).
Whitham, Murphy, Angel, Rahmsdorf, Smith, Lyons, Harris, Reynolds, Herrlich, Docherty: "Comparison of human stromelysin and collagenase by cloning and sequence analysis." in: The Biochemical journal, Vol. 240, Issue 3, pp. 913-6, (1987) (PubMed).
Goldberg, Wilhelm, Kronberger, Bauer, Grant, Eisen: "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein." in: The Journal of biological chemistry, Vol. 261, Issue 14, pp. 6600-5, (1986) (PubMed).
Aliases for Matrix Metallopeptidase 1 (Interstitial Collagenase) 蛋白