MARK1 抗体
(MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).
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Latest Publications for our MARK1 抗体
: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).: "Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2." in: The Journal of biological chemistry, Vol. 281, Issue 37, pp. 27586-99, (2006) (PubMed).
Aliases for MARK1 抗体
MAP/microtubule affinity-regulating kinase 1 S homeolog (mark1.S) 抗体microtubule affinity regulating kinase 1 (MARK1) 抗体
MAP/microtubule affinity-regulating kinase 1 (mark1) 抗体
microtubule affinity regulating kinase 1 (mark1) 抗体
MAP/microtubule affinity regulating kinase 1 (Mark1) 抗体
microtubule affinity regulating kinase 1 (Mark1) 抗体
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