(Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]\; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010].
Tada, Zhang, Koyama, Tobiume, Tsunetsugu-Yokota, Yamaoka, Fujita, Tokunaga: "MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins." in: Nature medicine, Vol. 21, Issue 12, pp. 1502-7, (2015) (PubMed).
Bartee, Mansouri, Hovey Nerenberg, Gouveia, Früh: "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins." in: Journal of virology, Vol. 78, Issue 3, pp. 1109-20, (2004) (PubMed).
Goto, Ishido, Sato, Ohgimoto, Ohgimoto, Nagano-Fujii, Hotta: "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 14657-68, (2003) (PubMed).