MAPKAP Kinase 5 抗体
(Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].
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Latest Publications for our MAPKAP Kinase 5 抗体
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).: "Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition." in: Toxicon : official journal of the International Society on Toxinology, Vol. 55, Issue 4, pp. 827-37, (2010) (PubMed).
: "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs." in: Science signaling, Vol. 2, Issue 94, pp. ra69, (2009) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 97, Issue 8, pp. 629-40, (2005) (PubMed).
: "Effect of different dietary ideal protein concentrations on broiler performance." in: British poultry science, Vol. 45, Issue 4, pp. 504-11, (2004) (PubMed).
: "Regulation of PRAK subcellular location by p38 MAP kinases." in: Molecular biology of the cell, Vol. 14, Issue 6, pp. 2603-16, (2003) (PubMed).
: "p62 functions as a p38 MAP kinase regulator." in: Biochemical and biophysical research communications, Vol. 269, Issue 2, pp. 521-5, (2000) (PubMed).
Aliases for MAPKAP Kinase 5 抗体
mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) 抗体mitogen-activated protein kinase-activated protein kinase 5 (mapkapk5) 抗体
MAP kinase-activated protein kinase 5 (Mapkapk5) 抗体
mitogen-activated protein kinase-activated protein kinase 5 (Mapkapk5) 抗体
MAPKAP-K5 抗体
MAPKAPK5 抗体
MK-5 抗体
MK5 抗体
PRAK 抗体
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