This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Tatsumi, Kierstead, Ranieri, Gesualdo, Schena, Finke, Bukowski, Brusic, Sidney, Sette, Logan, Kasamon, Slingluff, Kirkwood, Storkus: "MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 3, pp. 947-54, (2003) (PubMed).
Tatsumi, Kierstead, Ranieri, Gesualdo, Schena, Finke, Bukowski, Mueller-Berghaus, Kirkwood, Kwok, Storkus: "Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma." in: The Journal of experimental medicine, Vol. 196, Issue 5, pp. 619-28, (2002) (PubMed).
Aliases for MAGEA6 抗体
melanoma antigen, family A, 6 (Magea6) 抗体 MAGE family member A6 (MAGEA6) 抗体 CT1.6 抗体 MAGE-3b 抗体 Mage-a6 抗体 MAGE3B 抗体 MAGE6 抗体