This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Yang, Xu, Lu, Li, Sun, Guo, Xue, Guan: "Quantitative Analysis of Differential Proteome Expression in Bladder Cancer vs. Normal Bladder Cells Using SILAC Method." in: PLoS ONE, Vol. 10, Issue 7, pp. e0134727, (2015) (PubMed).
Kawada, Wada, Isobe, Gnjatic, Nishikawa, Jungbluth, Okazaki, Uenaka, Nakamura, Fujiwara, Mizuno, Saika, Ritter, Yamasaki, Miyata, Ritter, Murphy, Venhaus, Pan, Old, Doki, Nakayama: "Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination." in: International journal of cancer. Journal international du cancer, Vol. 130, Issue 3, pp. 584-92, (2011) (PubMed).
Nagao, Higashitsuji, Nonoguchi, Sakurai, Dawson, Mayer, Itoh, Fujita: "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10668-74, (2003) (PubMed).
Resnick, Sabo, Kondratev, Kerner, Spagnoli, Yakirevich: "Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous carcinomas." in: International journal of cancer. Journal international du cancer, Vol. 101, Issue 2, pp. 190-5, (2002) (PubMed).
Aliases for MAGEA4 抗体
melanoma antigen, family A, 4 (Magea4) 抗体 MAGE family member A4 (MAGEA4) 抗体 CT1.4 抗体 MAGE-41 抗体 Mage-a4 抗体 MAGE-X2 抗体 MAGE4 抗体 MAGE4A 抗体 MAGE4B 抗体 MAGEA4 抗体