Lysine (K)-Specific Methyltransferase 2A 抗体
(Lysine (K)-Specific Methyltransferase 2A (KMT2A))
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
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Lysine (K)-Specific Methyltransferase 2A 抗体
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Recommended Lysine (K)-Specific Methyltransferase 2A 抗体
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Latest Publications for our Lysine (K)-Specific Methyltransferase 2A Products
: "HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice." in: Cancer cell, Vol. 36, Issue 6, pp. 645-659.e8, (2019) (PubMed).: "Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development." in: Cell reports, Vol. 16, Issue 4, pp. 1039-54, (2016) (PubMed).
: "Epigenetic regulation of IL-12-dependent T cell proliferation." in: Journal of leukocyte biology, Vol. 98, Issue 4, pp. 601-13, (2015) (PubMed).
: "Reduction of Hox gene expression by histone H1 depletion." in: PLoS ONE, Vol. 7, Issue 6, pp. e38829, (2012) (PubMed).
: "Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia." in: PLoS genetics, Vol. 8, Issue 6, pp. e1002781, (2012) (PubMed).
: "Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 3, pp. 1182-92, (2012) (PubMed).
: "Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation." in: PLoS genetics, Vol. 8, Issue 7, pp. e1002840, (2012) (PubMed).
: "MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome." in: Blood, Vol. 117, Issue 25, pp. 6895-905, (2011) (PubMed).
: "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}." in: The Journal of biological chemistry, Vol. 286, Issue 2, pp. 1354-63, (2011) (PubMed).
: "Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies." in: Molecular and cellular biology, Vol. 30, Issue 8, pp. 2046-56, (2010) (PubMed).
Synonyms and alternative names related to Lysine (K)-Specific Methyltransferase 2A
lysine (K)-specific methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, mKIAA4050, Mll, Mll1Protein level used designations for Lysine (K)-Specific Methyltransferase 2A
- histone-lysine N-methyltransferase 2A
- histone-lysine N-methyltransferase MLL
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia 1
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax Drosophila
- zinc finger protein HRX
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