The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Kallio, Marchesani, Vlachopoulou, Mäntylä, Paju, Buhlin, Suominen, Contreras, Knuuttila, Hernandez, Huumonen, Nieminen, Perola, Sinisalo, Lokki, Pussinen: "Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis." in: Infection and immunity, Vol. 82, Issue 5, pp. 1939-48, (2014) (PubMed).
Jeong, Kim, Moon, Song, Choi, Kim, Kim, An: "Targeted inhibition of phosphatidyl inositol-3-kinase p110?, but not p110?, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers." in: Apoptosis : an international journal on programmed cell death, Vol. 18, Issue 4, pp. 509-20, (2013) (PubMed).
Pfeffer: "Biological functions of tumor necrosis factor cytokines and their receptors." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 185-91, (2003) (PubMed).
Meager, Parti, Leung, Woolley, Peil, Sidhu, Roberts: "A two-site sandwich immunoradiometric assay of human lymphotoxin with monoclonal antibodies and its applications." in: Journal of immunological methods, Vol. 104, Issue 1-2, pp. 31-42, (1988) (PubMed).
Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).