(LSM1 Homolog, U6 Small Nuclear RNA Associated (LSM1))
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011].
Jhanji, Lee, Watson, Hinds, Pearse: "Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications." in: Intensive care medicine, Vol. 35, Issue 4, pp. 671-7, (2009) (PubMed).