(Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1))
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Khachigian, Santiago, Rafty, Chan, Delbridge, Bobik, Collins, Johnson: "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury." in: Circulation research, Vol. 84, Issue 11, pp. 1258-67, (1999) (PubMed).
Reed, Yamazaki, Kaufman, Rubinstein, Murphy, Johnson: "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21594-602, (1998) (PubMed).
Wilson, Brown, Kingsman, Kingsman: "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." in: Nucleic acids research, Vol. 26, Issue 15, pp. 3460-7, (1998) (PubMed).