LPIN3 产品
(Lipin 3 (LPIN3))
Categories
Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.\; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively. [provided by RefSeq, Jul 2008].
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Featured LPIN3 Categories
Recommended LPIN3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN185722
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN2613198
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
Cat. No.
ABIN2613200
Quantity
100 μL
Datasheet
Datasheet
Recommended LPIN3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3093602
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3137000
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2724799
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our LPIN3 Products
: "The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth." in: The EMBO journal, Vol. 24, Issue 11, pp. 1931-41, (2005) (PubMed).Synonyms and alternative names related to LPIN3
lipin 3 L homeolog (lpin3.L), lipin 3 (LPIN3), lipin 3 (LOAG_08747), lipin 3 (lpin3), lipin 3 (Lpin3), 9130206L11Rik, AA438110, AV236139, dJ450M14.2, dJ450M14.3, dJ620E11.2, DKFZp469D075, LIPN3L, LPIN3, MGC82840, mKIAA4023, SMP2Protein level used designations for LPIN3
- lipin 3
- phosphatidate phosphatase LPIN3
- phosphatidate phosphatase LPIN3-like
- lipin-3
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