LITAF 抗体
(Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].
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Latest Publications for our LITAF 抗体
: "Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes." in: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1619-37, S1-3, (2013) (PubMed).: "LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 37, pp. 13777-82, (2006) (PubMed).
: "SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation." in: Human mutation, Vol. 25, Issue 4, pp. 372-83, (2005) (PubMed).
: "Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 23065-76, (2001) (PubMed).
: "A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4518-23, (1999) (PubMed).
Aliases for LITAF 抗体
lipopolysaccharide induced TNF factor (LITAF) 抗体lipopolysaccharide-induced TNF factor (Litaf) 抗体
LPS-induced TN factor (Litaf) 抗体
3222402J11Rik 抗体
C85531 抗体
EET-1 抗体
N4WBP3 抗体
PIG7 抗体
Pig7 抗体
SIMPLE 抗体
TBX1 抗体
TNF-alpha 抗体
TP53I7 抗体
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