LIG4 蛋白
(Ligase IV, DNA, ATP-Dependent (LIG4))
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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5 results
custom-made
LIG4
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
custom-made
LIG4
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
Aliases for LIG4 蛋白
ligase IV, DNA, ATP-dependent (lig4) 蛋白DNA ligase 4 (LIG4) 蛋白
DNA ligase 4 (LOC100212302) 蛋白
DNA ligase 4 (CpipJ_CPIJ005161) 蛋白
DNA ligase 4 (PTRG_09982) 蛋白
DNA ligase 4 (MCYG_05151) 蛋白
DNA ligase 4 (LOC657210) 蛋白
ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) 蛋白
DNA ligase IV (ATLIG4) 蛋白
ligase IV, DNA, ATP-dependent L homeolog (lig4.L) 蛋白
ligase IV, DNA, ATP-dependent (Lig4) 蛋白
DNA ligase 4 (Lig4) 蛋白
5830471N16Rik 蛋白
DNA LIGASE IV 蛋白
DNL4 蛋白
lig4 蛋白
LIG4 蛋白
lig4-A 蛋白
tiny 蛋白
zgc:165595 蛋白
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