This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Li, Ponten, dos Remedios: "The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development." in: Proteomics, Vol. 12, Issue 2, pp. 203-25, (2012) (PubMed).