(Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6 (LGR6))
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Liao, Nguyen: "Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells." in: Experimental dermatology, Vol. 23, Issue 3, pp. 195-8, (2014) (PubMed).
Steffen, Simon, Warneke, Balschun, Ebert, Röcken: "LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma." in: Virchows Archiv : an international journal of pathology, Vol. 461, Issue 4, pp. 355-65, (2012) (PubMed).
Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: "Identification of stem cells in small intestine and colon by marker gene Lgr5." in: Nature, Vol. 449, Issue 7165, pp. 1003-7, (2007) (PubMed).