LATS2 抗体
(LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
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Latest Publications for our LATS2 抗体
: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
: "Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR ..." in: The Journal of biological chemistry, Vol. 291, Issue 34, pp. 17988-8005, (2016) (PubMed).
: "LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade." in: Oncogene, Vol. 34, Issue 1, pp. 73-83, (2015) (PubMed).
: "Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors." in: Molecular therapy. Nucleic acids, Vol. 4, pp. e246, (2015) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2." in: Nature cell biology, Vol. 16, Issue 10, pp. 962-71, 1-8, (2014) (PubMed).
: "The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl." in: Cell death and differentiation, Vol. 20, Issue 10, pp. 1330-40, (2013) (PubMed).
: "KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34069-77, (2012) (PubMed).
: "Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation." in: The EMBO journal, Vol. 31, Issue 1, pp. 29-43, (2012) (PubMed).
Aliases for LATS2 抗体
large tumor suppressor kinase 2 (LATS2) 抗体large tumor suppressor 2 (Lats2) 抗体
large tumor suppressor kinase 2 (Lats2) 抗体
large tumor suppressor kinase 2 (lats2) 抗体
4932411G09Rik 抗体
AV277261 抗体
AW228608 抗体
KPM 抗体
lats2 抗体
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