Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Hori, Miyake, Onishi, Tatsumi, Morizawa, Nakai, Anai, Tanaka, Fujimoto: "Clinical significance of α‑ and β‑Klotho in urothelial carcinoma of the bladder." in: Oncology reports, Vol. 36, Issue 4, pp. 2117-25, (2016) (PubMed).